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KMID : 0370220100540050387
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Yakhak Hoeji
2010 Volume.54 No. 5 p.387 ~ p.391
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Inhibition of Nitric Oxide Production by Anthraquinones from Polygonum cuspidatum
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Joo Si-Mong
Yang Ki-Sook
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Abstract
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Polygonum cuspidatum which is widely distributed in Korea has been used as treatments of dermatitis, gonorrhea and inflammation in traditional medicine. We examined anti-inflammatory activities by the inhibition of NO production in RAW264.7 murine macrophages cells. Phytochemical examination of Polygonum cuspidatum led to the isolation and characterization of emodin (1), emodin 8-O--D-glucopyranoside (2), emodin 1-O--D-glucopyranoside (3). Antioxidative activities of these compounds were determined by measuring the radical scavenging effects on DPPH radicals. Compounds 1 and 3 showed potent activities compared with L-NMMA. These results suggested that the antraquinone compounds isolated from Polygonum cuspidatum might be used as antiinflammatory agents.
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KEYWORD
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Polygonum cuspidatum, emodin, emodin 8-O--D-glucopyranoside, emodin 1-O--D-glucopyranoside, antiinflammatory agents
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